| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Curcumin | 📋 | ✍ | ⛔ | | 36676983 | Curcumin Decreases Viability and Inhibits Proliferation of Imatinib-Sensitive and Imatinib-Resistant Chronic Myeloid Leukemia Cell Lines |
| Resveratrol | 📋 | ✍ | ⛔ | | 38387900 | [Resveratrol Inhibits T-acute Lymphoblastic Leukemia in Mice by Regulating Notch1 Signaling Pathway] |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38707638 | 20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3 |
| Quercetin | 📋 | ✍ | ⛔ | | 36148953 | Quercetin induces autophagy-associated death in HL-60 cells through CaMKKβ/AMPK/mTOR signal pathway |
| EGCG | 📋 | ✍ | ⛔ | | 36291849 | EGCG Prevents the Transcriptional Reprogramming of an Inflammatory and Immune-Suppressive Molecular Signature in Macrophage-like Differentiated Human HL60 Promyelocytic Leukemia Cells |
| Vitamin C | 📋 | ✍ | ⛔ | | 37671973 | Vitamin C and D Supplementation in Acute Myeloid Leukemia |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38268604 | A label free chemoproteomic-based platform to disclose cannabidiol molecular mechanism of action on chronic myelogenous leukemia cancer cells |
| Retinoic Acid | 📋 | | | | 38204257 | Combination of Ethacrynic Acid and ATRA Triggers Differentiation and/or Apoptosis of Acute Myeloid Leukemia Cells through ROS |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 37671973 | Vitamin C and D Supplementation in Acute Myeloid Leukemia |
| Wogonin | 📋 | ✍ | ⛔ | | 38698063 | On the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation |
| Berberine | 📋 | ✍ | ⛔ | | 36871981 | Berberine targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia with IDH1 mutation |
| Kaempferol | 📋 | ✍ | ⛔ | | 37096500 | [Inhibitory Effect of Kaempferol on Proliferation of KG1a Cells and Its Mechanism] |
| Melatonin | 📋 | ✍ | ⛔ | | 37645444 | Melatonin as a regulator of apoptosis in leukaemia: molecular mechanism and therapeutic perspectives |
| Sulforaphane | 📋 | ✍ | ⛔ | | 35182064 | The Inhibitory Effect of Sulforaphane on The Proliferation of Acute Myeloid Leukemia Cell Lines through Controlling miR-181a |
| Thymoquinone | 📋 | | ⛔ | | 37375831 | Thymoquinone Enhances Apoptosis of K562 Chronic Myeloid Leukemia Cells through Hypomethylation of SHP-1 and Inhibition of JAK/STAT Signaling Pathway |
| Fisetin | 📋 | ✍ | ⛔ | | 31638196 | Cellular and molecular alterations induced by low‑dose fisetin in human chronic myeloid leukemia cells |
| Andrographolide | 📋 | | | | 38357243 | Andrographolide acts with dexamethasone to inhibit the growth of acute lymphoblastic leukemia CEM‑C1 cells via the regulation of the autophagy‑dependent PI3K/AKT/mTOR signaling pathway |
| Dihydroartemisinin | 📋 | | | | 38459729 | Formononetin and Dihydroartemisinin Act Synergistically to Induce Apoptosis in Human Acute Myeloid Leukemia Cell Lines |
| Pterostilbene | 📋 | ✍ | ⛔ | | 35027628 | Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells |
| Gallic Acid | 📋 | | ⛔ | | 38062274 | The Effects of Resveratrol, Gallic Acid, and Piperine on the Expression of miR-17, miR-92b, miR-181a, miR-222, BAX, BCL-2, MCL-1, WT1, c-Kit, and CEBPA in Human Acute Myeloid Leukemia Cells and Their Roles in Apoptosis |
| Genistein | 📋 | ✍ | ⛔ | | 35608747 | Molecular effects of genistein, as a potential anticancer agent, on CXCR-4 and VEGF pathway in acute lymphoblastic leukemia |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 33754891 | Immunomodulatory Effect of Green Tea Treatment in Combination with Low-dose Chemotherapy in Elderly Acute Myeloid Leukemia Patients with Myelodysplasia-related Changes |
| Luteolin | 📋 | ✍ | ⛔ | | 38150934 | Discovery and characterization of natural product luteolin as an effective inhibitor of human pyridoxal kinase |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 35763830 | Ganoderma lucidum polysaccharide inhibits the proliferation of leukemic cells through apoptosis |
| Tanshinone | 📋 | | | | 38706059 | [Study on the inhibitory and pro-apoptotic effects of different concentrations of total tanshinone alone and in combination with tyrosine kinase inhibitors on human myeloid leukemia cell lines] |
| Blueberry | 📋 | ✍ | ⛔ | | 35631768 | Prediction of the Adult T-Cell Leukemia Inhibitory Activity of Blueberry Leaves/Stems Using Direct-Injection Electron Ionization-Mass Spectrometry Metabolomics |
| Cinnamon | 📋 | ✍ | ⛔ | | 35579734 | Combined efficacy of Cinnamomum zeylanicum and doxorubicin against leukemia through regulation of TRAIL and NF-kappa B pathways in rat model |
| Gingerol | 📋 | ✍ | | | 32483405 | Bioinformatics and Experimental Studies of Anti-Leukemic Activity From 6-gingerol Demonstrate Its Role in p53 Mediated Apoptosis Pathway |
| Hesperetin | 📋 | | | | 38423637 | Azacitidine-Hesperetin Combination Induces S-phase Cell Cycle Arrest and Apoptosis in Human Leukemia Cells |
| Metformin | 📋 | ✍ | ⛔ | | 38286894 | Research Progress on the Use of Metformin in Leukemia Treatment |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 34884437 | N-acetylcysteine Can Induce Massive Oxidative Stress, Resulting in Cell Death with Apoptotic Features in Human Leukemia Cells |
| Naringenin | 📋 | ✍ | ⛔ | | 38116560 | Co-treatment of Naringenin and Ketoprofen-RGD Suppresses Cell Proliferation via Calmodulin/PDE/cAMP/PKA Axis Pathway in Leukemia and Ovarian Cancer Cells |
| Pomegranate | 📋 | | ⛔ | | 37886154 | Tumor regression efficacy of Punica granatum L leaf extract against K562 leukemia cancer cells |
| Puerarin | 📋 | ✍ | ⛔ | | 33141989 | Puerarin sensitized K562/ADR cells by inhibiting NF-κB pathway and inducing autophagy |
| Apigenin | 📋 | ✍ | ⛔ | | 36753951 | The anti-leukemic activity of a luteolin-apigenin enriched fraction from an edible and ethnomedicinal plant, Elsholtzia stachyodes, is exerted through an ER stress/autophagy/cell cycle arrest/ apoptotic cell death signaling axis |
| Artemisinin | 📋 | | | | 38104159 | Artesunate acts through cytochrome c to inhibit growth of pediatric AML cells |
| Baicalein | 📋 | ✍ | ⛔ | | 36869331 | Induction of DNMT1-dependent demethylation of SHP-1 by the natural flavonoid compound Baicalein overcame Imatinib-resistance in CML CD34+ cells |
| Bay Leaf | 📋 | | ⛔ | | 22017546 | Antioxidant and antiproliferative activity of Laurus nobilis L. (Lauraceae) leaves and seeds essential oils against K562 human chronic myelogenous leukaemia cells |
| Bee Venom | 📋 | ✍ | ⛔ | | 35205267 | Sweet Bee Venom Triggers Multiple Cell Death Pathways or Spurs Acute Cell Rupture According to Its Concentration in THP-1 Monocytic Leukemia Cells |
| Burdock | 📋 | | ⛔ | | 33138135 | Induction of Apoptosis, Autophagy and Ferroptosis by Thymus vulgaris and Arctium lappa Extract in Leukemia and Multiple Myeloma Cell Lines |
| Carnosic Acid | 📋 | | | | 30003745 | Carnosic acid regulates cell proliferation and invasion in chronic myeloid leukemia cancer cells via suppressing microRNA-708 |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 36854499 | Docosahexaenoic Acid Potentiates the Anticancer Effect of the Menadione/Ascorbate Redox Couple by Increasing Mitochondrial Superoxide and Accelerating ATP Depletion |
| Echinacea | 📋 | ✍ | ⛔ | | 26626240 | Interactions Between Nutraceutical Supplements and Standard Acute Myeloid Leukemia Chemotherapeutics |
| Fucoidan | 📋 | ✍ | ⛔ | | 26324225 | Fucoidan inhibits proliferation of the SKM-1 acute myeloid leukaemia cell line via the activation of apoptotic pathways and production of reactive oxygen species |
| Ginseng | 📋 | ✍ | ⛔ | | 37205671 | Ginsenoside 24-OH-PD from red ginseng inhibits acute T-lymphocytic leukaemia by activating the mitochondrial pathway |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 35116693 | Grape seed proanthocyanidin extract induces apoptosis of HL-60/ADR cells via the Bax/Bcl-2 caspase-3/9 signaling pathway |
| Honokiol | 📋 | | | | 38573223 | Honokiol induces apoptosis and autophagy in dexamethasone-resistant T-acute lymphoblastic leukemia CEM-C1 cells |
| Rapamycin | 📋 | ✍ | | | 38530586 | Rapamycin increases leukemia cell sensitivity to chemotherapy by regulating mTORC1 pathway-mediated apoptosis and autophagy |
| Silymarin | 📋 | ✍ | ⛔ | | 38283627 | Effect of oral silymarin on liver function in pediatric acute lymphoblastic leukemia in the maintenance phase: a double-blind randomized clinical trial |
| Vitamin E | 📋 | ✍ | ⛔ | | 32231189 | Aberrant Expression of Placental-Like Alkaline Phosphatase in Chronic Myeloid Leukemia Cells in Vitro and Its Modulation by Vitamin E |
| Withaferin A | 📋 | | | | 35204712 | Computational Identification of BCR-ABL Oncogenic Signaling as a Candidate Target of Withaferin A and Withanone |
| Anthocyanins | 📋 | ✍ | ⛔ | | 35924786 | Calcicoptosis induced by purple sweet potato anthocyanins through the nonosmotic regulation of the NFAT5/S100A4-S100A9 pathway in acute lymphoblastic leukemia |
| Ashwagandha | 📋 | ✍ | ⛔ | | 35204712 | Computational Identification of BCR-ABL Oncogenic Signaling as a Candidate Target of Withaferin A and Withanone |
| Betulinic Acid | 📋 | | | | 34573088 | Betulinic Acid-Doxorubicin-Drug Combination Induced Apoptotic Death via ROS Stimulation in a Relapsed AML MOLM-13 Cell Model |
| Carrot | 📋 | | ⛔ | | 27275246 | Beetroot-Carrot Juice Intake either Alone or in Combination with Antileukemic Drug 'Chlorambucil' As A Potential Treatment for Chronic Lymphocytic Leukemia |
| Cat's Claw | 📋 | ✍ | ⛔ | | 18048957 | Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells |
| Diallyl Disulfide | 📋 | | | | 36793247 | Diallyl disulfide downregulating RhoGDI2 induces differentiation and inhibit invasion via the Rac1/Pak1/LIMK1 pathway in human leukemia HL-60 cells |
| Indian Gooseberry | 📋 | | ⛔ | | 34850958 | Corilagin induces apoptosis and inhibits autophagy of HL‑60 cells by regulating miR‑451/HMGB1 axis |
| Mangiferin | 📋 | | ⛔ | | 32889744 | Mangiferin induces immune responses and evaluates the survival rate in WEHI-3 cell generated mouse leukemia in vivo |
| Nobiletin | 📋 | ✍ | | | 32260160 | Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 36741365 | Olive leaves extract alleviates inflammation and modifies the intrinsic apoptotic signal in the leukemic bone marrow |
| Phytochemicals | 📋 | | | | 38566147 | Natural products as potential drug treatments for acute promyelocytic leukemia |
| Piperine | 📋 | ✍ | ⛔ | | 38062274 | The Effects of Resveratrol, Gallic Acid, and Piperine on the Expression of miR-17, miR-92b, miR-181a, miR-222, BAX, BCL-2, MCL-1, WT1, c-Kit, and CEBPA in Human Acute Myeloid Leukemia Cells and Their Roles in Apoptosis |
| Raspberry | 📋 | ✍ | ⛔ | | 30037097 | Antioxidant, Anti-Inflammatory, and Postulated Cytotoxic Activity of Phenolic and Anthocyanin-Rich Fractions From Polana Raspberry ( Rubus idaeus L.) Fruit and Juice-In Vitro Study |
| Salidroside | 📋 | | | | 36369630 | Mechanism of salidroside in the treatment of chronic myeloid leukemia based on the network pharmacology and molecular docking |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 33761611 | Multidirectional effects of saponin fraction isolated from the leaves of sea buckthorn Elaeagnus rhamnoides (L.) A. Nelson |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 33675488 | The Agglutinin of Common Nettle (Urtica dioica L.) Plant Effects on Gene Expression Related to Apoptosis of Human Acute Myeloid Leukemia Cell Line |
| Withanolides | 📋 | | | | 35204712 | Computational Identification of BCR-ABL Oncogenic Signaling as a Candidate Target of Withaferin A and Withanone |
| Acacetin | 📋 | | | | 27779444 | Selective Anticancer Activity of Acacetin Against Chronic Lymphocytic Leukemia Using Both In Vivo and In Vitro Methods: Key Role of Oxidative Stress and Cancerous Mitochondria |
| Allicin | 📋 | ✍ | ⛔ | | 29950084 | [Effect of Allicin on Proliferation and Apoptosis of KG-1 Cells and Its Molecular Mechanism] |
| Aloe-Emodin | 📋 | | | | 21978786 | Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells |
| Amygdalin | 📋 | ✍ | ⛔ | | 31649801 | Apoptosis Induction of Armeniacae Semen Extractin Human Acute Leukemia (NALM-6 and KG-1) Cells |
| Arctigenin | 📋 | | | | 38660844 | [Reversal Effect of Arctigenin on the Drug Resistance in Leukemia K562/A02 Cells and Its Mechanism] |
| Astaxanthin | 📋 | ✍ | ⛔ | | 35441937 | Astaxanthin decreases the growth-inhibitory dose of cytarabine and inflammatory response in the acute lymphoblastic leukemia cell line NALM-6 |
| Baicalin | 📋 | ✍ | ⛔ | | 31881375 | Antitumor effect of baicalin from the Scutellaria baicalensis radix extract in B-acute lymphoblastic leukemia with different chromosomal rearrangements |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 33413604 | In vitro anti-proliferative activity of selected nutraceutical compounds in human cancer cell lines |
| Bilberry | 📋 | ✍ | ⛔ | | 25757575 | Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 36499332 | A Central Contribution of TG2 Activity to the Antiproliferative and Pro-Apoptotic Effects of Caffeic Acid in K562 Cells of Human Chronic Myeloid Leukemia |
| Capsaicin | 📋 | ✍ | ⛔ | | 33413604 | In vitro anti-proliferative activity of selected nutraceutical compounds in human cancer cell lines |
| Carvacrol | 📋 | ✍ | ⛔ | | 35395969 | [Effect of Carvacrol on the Biological Behavior of Leukemia Cells and Its Mechanism] |
| Chokeberry | 📋 | ✍ | ⛔ | | 22412883 | Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells |
| Cordycepin | 📋 | | | | 37568748 | Cordycepin (3'dA) Induces Cell Death of AC133+ Leukemia Cells via Re-Expression of WIF1 and Down-Modulation of MYC |
| Cranberry | 📋 | ✍ | ⛔ | | 32143616 | Cranberry extract initiates intrinsic apoptosis in HL-60 cells by increasing BAD activity through inhibition of AKT phosphorylation |
| Cyanidin | 📋 | ✍ | | | 27444805 | Anthocyanins From Roselle Extract Arrest Cell Cycle G2/M Phase Transition via ATM/Chk Pathway in p53-deficient Leukemia HL-60 Cells |
| Dandelion | 📋 | ✍ | ⛔ | | 30662779 | The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia |
| Delphinidin | 📋 | | | | 27444805 | Anthocyanins From Roselle Extract Arrest Cell Cycle G2/M Phase Transition via ATM/Chk Pathway in p53-deficient Leukemia HL-60 Cells |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 33924032 | Ampelopsin Inhibits Cell Proliferation and Induces Apoptosis in HL60 and K562 Leukemia Cells by Downregulating AKT and NF-κB Signaling Pathways |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 30838722 | Antitumour effects of selected plant polyphenols, gallic acid and ellagic acid, on sensitive and multidrug-resistant leukaemia HL60 cells |
| Emodin | 📋 | | ⛔ | | 32999163 | Emodin Inhibits Resistance to Imatinib by Downregulation of Bcr-Abl and STAT5 and Allosteric Inhibition in Chronic Myeloid Leukemia Cells |
| Escin | 📋 | ✍ | ⛔ | | 21452372 | Escin sodium induces apoptosis of human acute leukemia Jurkat T cells |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 22972479 | Glycyrrhizic acid induces apoptosis in WEHI-3 mouse leukemia cells through the caspase- and mitochondria-dependent pathways |
| Hesperidin | 📋 | ✍ | ⛔ | | 36534417 | Evidence for Hesperidin as an Effective Factor in Initiating the Intrinsic Pathway of Apoptosis in KG1a Leukemia Cells |
| Holy Basil | 📋 | ✍ | ⛔ | | 37110523 | Inhibitory Potential of the Ocimum sanctum Phytochemicals on Bruton's Tyrosine Kinase, a Well-Known Drug Target for Treatment of Chronic Lymphocytic Leukemia: An In Silico Investigation |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 33148846 | THE EFFECT OF α-LIPOIC ACID ON THE FUNCTIONAL STATE OF PERIPHERAL NERVE FIBERS IN POLYNEUROPATHY OF THE LOWER EXTREMITIES IN PATIENTS WITH CHRONIC HEMOBLASTOSIS |
| Loquat | 📋 | ✍ | ⛔ | | 23429195 | Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines |
| Medicinal Plants | 📋 | | | | 38566147 | Natural products as potential drug treatments for acute promyelocytic leukemia |
| Myricetin | 📋 | | ⛔ | | 36730418 | Myricetin is effective and selective in inhibiting imatinib-resistant chronic myeloid leukemia stem and differentiated cells through targeting eIF4E |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 31781612 | Nigella sativa Oil Mouth Rinse Improves Chemotherapy-Induced Oral Mucositis in Patients with Acute Myeloid Leukemia |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 37124732 | Effect of long-chain omega-3 polyunsaturated fatty acids on cardiometabolic factors in children with acute lymphoblastic leukemia undergoing treatment: a secondary analysis of a randomized controlled trial |
| Orange | 📋 | | ⛔ | | 26434864 | Chemopreventive Actions of Blond and Red-Fleshed Sweet Orange Juice on the Loucy Leukemia Cell Line |
| Parthenolide | 📋 | | | | 37298119 | Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies |
| Peanut | 📋 | | ⛔ | | 21067217 | Arachidin-1, a peanut stilbenoid, induces programmed cell death in human leukemia HL-60 cells |
| Piperlongumine | 📋 | | | | 36220508 | Piperlongumine overcomes imatinib resistance by inducing proteasome inhibition in chronic myelogenous leukemia cells |
| Polydatin | 📋 | ✍ | | | 35894200 | [Effect of polydatin on the proliferation and apoptosis of THP-1 cells and the mechanism] |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 33133551 | Characterization of pomegranate peel extracts obtained using different solvents and their effects on cell cycle and apoptosis in leukemia cells |
| Punicalagin | 📋 | ✍ | ⛔ | | 34760363 | Punicalagin, a pomegranate compound, induces apoptosis and autophagy in acute leukemia |
| Roselle | 📋 | ✍ | ⛔ | | 27444805 | Anthocyanins From Roselle Extract Arrest Cell Cycle G2/M Phase Transition via ATM/Chk Pathway in p53-deficient Leukemia HL-60 Cells |
| Rosemary | 📋 | ✍ | ⛔ | | 16395705 | Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia |
| Rosmarinic Acid | 📋 | ✍ | | | 37110523 | Inhibitory Potential of the Ocimum sanctum Phytochemicals on Bruton's Tyrosine Kinase, a Well-Known Drug Target for Treatment of Chronic Lymphocytic Leukemia: An In Silico Investigation |
| Rutin | 📋 | ✍ | ⛔ | | 20015448 | Vitamin E and Rutin Synergistically Inhibit Expression of Vascular Endothelial Growth Factor Through Down-Regulation of Binding Activity of Activator protein-1 in Human Promyelocytic Leukemia (HL-60) Cells |
| Scutellarin | 📋 | | | | 37096506 | [Effect of Scutellarin on Proliferation of Acute Myeloid Leukemia Cells and Its Related Mechanism] |
| Selenium | 📋 | ✍ | ⛔ | | 33723167 | Antitumor effects of sodium selenite on acute lymphocytic leukemia |
| Sesamin | 📋 | ✍ | | | 36397810 | Sesamin Acts as Anti-leukemic Compound Interacting with Novel Phosphoprotein Targets and Inducing Apoptosis in Leukemic Cells |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 14580685 | Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis |
| Shogaol | 📋 | | | | 33939282 | 6-Shogaol induces apoptosis in acute lymphoblastic leukaemia cells by targeting p53 signalling pathway and generation of reactive oxygen species |
| Silibinin | 📋 | ✍ | | | 26148599 | Enhancement of the cytotoxic effects of Cytarabine in synergism with Hesperidine and Silibinin in Acute Myeloid Leukemia: An in-vitro approach |
| Tetrahydrocurcumin | 📋 | ✍ | | | 30834607 | Curcumin and Tetrahydrocurcumin Induce Cell Death in Ara-C-resistant Acute Myeloid Leukemia |
| Tomato | 📋 | | ⛔ | | 25625536 | α-Tomatine inhibits growth and induces apoptosis in HL-60 human myeloid leukemia cells |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 34641483 | Quassinoids from the Roots of Eurycoma longifolia and Their Anti-Proliferation Activities |
| Trans-Resveratrol | 📋 | | | | 23161277 | Cytotoxic Effect of Natural Trans-Resveratrol Obtained From Elicited Vitis Vinifera Cell Cultures on Three Cancer Cell Lines |
| Vitamin K | 📋 | ✍ | ⛔ | | 32305047 | Cytotoxic Effects of Vitamins K1, K2 and K3 Against Human T Lymphoblastoid Leukemia Cells Through Apoptosis Induction and Cell Cycle Arrest |
| Vitexin | 📋 | | | | 37110523 | Inhibitory Potential of the Ocimum sanctum Phytochemicals on Bruton's Tyrosine Kinase, a Well-Known Drug Target for Treatment of Chronic Lymphocytic Leukemia: An In Silico Investigation |
| Wormwood | 📋 | ✍ | ⛔ | | 31649803 | Methanolic Extract from Aerial Parts of Artemisia Annua L. Induces Cytotoxicity and Enhances Vincristine-Induced Anticancer Effect in Pre-B Acute Lymphoblastic Leukemia Cells |
| Zinc | 📋 | ✍ | ⛔ | | 35269710 | Zinc Prevents DNA Damage in Normal Cells but Shows Genotoxic and Cytotoxic Effects in Acute Myeloid Leukemia Cells |
| Acai Berry | 📋 | ✍ | ⛔ | | 16478240 | Açai (Euterpe oleracea Mart.) polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemia cells |
| Aged Garlic | 📋 | ✍ | ⛔ | | 24741395 | Induction of apoptosis by a hexane extract of aged black garlic in the human leukemic U937 cells |
| Aloe Vera | 📋 | ✍ | ⛔ | | 11007077 | Induction of Apoptosis in Human Leukaemic Cell Lines K562, HL60 and U937 by Diethylhexylphthalate Isolated From Aloe Vera Linne |
| Aloesin | 📋 | | | | 19941474 | Antitumor Properties and Modulation of Antioxidant Enzymes' Activity by Aloe Vera Leaf Active Principles Isolated via Supercritical Carbon Dioxide Extraction |
| Aloin | 📋 | | | | 19941474 | Antitumor Properties and Modulation of Antioxidant Enzymes' Activity by Aloe Vera Leaf Active Principles Isolated via Supercritical Carbon Dioxide Extraction |
| Angelica | 📋 | ✍ | ⛔ | | 25987027 | Angelica sinensis polysaccharide induces erythroid differentiation of human chronic myelogenous leukemia k562 cells |
| Asafoetida | 📋 | ✍ | ⛔ | | 31698777 | Farnesiferol C Induces Apoptosis in Chronic Myelogenous Leukemia Cells as an Imatinib Sensitizer via Caspase Activation and HDAC (Histone Deacetylase) Inactivation |
| Asiatic Acid | 📋 | | | | 25815462 | Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway |
| Astragalosides | 📋 | ✍ | ⛔ | | 21875462 | [Mechanism of apoptosis in human leukemia NB4 cells induced by total astragalosides] |
| Astragalus Root | 📋 | ✍ | ⛔ | | 22172162 | Astragalus membranaceus lectin (AML) induces caspase-dependent apoptosis in human leukemia cells |
| Avocado | 📋 | ✍ | ⛔ | | 26077472 | Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death |
| Balloon Flower | 📋 | ✍ | ⛔ | | 37541375 | Platycodin D induces apoptotic cell death through PI3K/AKT and MAPK/ERK pathways and synergizes with venetoclax in acute myeloid leukemia |
| Barberry | 📋 | ✍ | ⛔ | | 26122228 | BERBERIS VULGARIS FRUIT CRUDE EXTRACT AS A NOVEL ANTI-LEUKAEMIC AGENT |
| Basil | 📋 | ✍ | ⛔ | | 31604407 | Apoptosis of Leukemia Cells by Ocimum basilicum Fractions Following TNF alpha Induced Activation of JNK and Caspase 3 |
| Bee Propolis | 📋 | ✍ | ⛔ | | 16055186 | Evaluation of Manisa Propolis Effect on Leukemia Cell Line by Telomerase Activity |
| Bergamot | 📋 | ✍ | ⛔ | | 36297603 | The Anticancer Effect of a Flavonoid-Rich Extract of Bergamot Juice in THP-1 Cells Engages the SIRT2/AKT/p53 Pathway |
| Beta-Lapachone | 📋 | | | | 20438329 | Beta-lapachone (LAPA) decreases cell viability and telomerase activity in leukemia cells: suppression of telomerase activity by LAPA |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 17603173 | Beta-sitosterol Induces Anti-Proliferation and Apoptosis in Human Leukemic U937 Cells Through Activation of caspase-3 and Induction of Bax/Bcl-2 Ratio |
| Bitter Melon | 📋 | ✍ | ⛔ | | 36238266 | Anti-leukemic principle(s) from Momordica charantia seeds induce differentiation of HL-60 cells through ERK/MAPK signalling pathway |
| Black Pepper | 📋 | ✍ | ⛔ | | 33884168 | Black pepper and piperine induce anticancer effects on leukemia cell line |
| Boric Acid | 📋 | ✍ | ⛔ | | 38015327 | Boric Acid Affects Cell Proliferation, Apoptosis, and Oxidative Stress in ALL Cells |
| Bromelain | 📋 | ✍ | ⛔ | | 30453006 | Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition - A comparison with only bromelain |
| Capsanthin | 📋 | | | | 21620794 | Carotenoids Inhibit Proliferation and Regulate Expression of Peroxisome Proliferators-Activated Receptor Gamma (PPARγ) in K562 Cancer Cells |
| Catechins | 📋 | | | | 9255971 | Inhibitory effects of persimmon (Diospyros kaki) extract and related polyphenol compounds on growth of human lymphoid leukemia cells |
| Cinnamic Acid | 📋 | | | | 35585382 | Ethacrynic acid and cinnamic acid combination exhibits selective anticancer effects on K562 chronic myeloid leukemia cells |
| Citral | 📋 | | | | 14758720 | Induction of apoptosis by Citrus paradisi essential oil in human leukemic (HL-60) cells |
| Coconut | 📋 | | ⛔ | | 17713650 | The husk fiber of Cocos nucifera L. (Palmae) is a source of anti-neoplastic activity |
| Colostrum | 📋 | ✍ | ⛔ | | 37174290 | Utilization of Dairy By-Products as a Source of Functional and Health Compounds-The Role of Ovine Colostrum and Milk Whey on Chronic Myeloid Leukemia Cells |
| Copper | 📋 | ✍ | ⛔ | | 20032896 | Cytotoxic Activity of Curcumin Towards CCRF-CEM Leukemia Cells and Its Effect on DNA Damage |
| Cordyceps | 📋 | ✍ | ⛔ | | 35497915 | Antileukaemic Cell Proliferation and Cytotoxic Activity of Edible Golden Cordyceps ( Cordyceps militaris) Extracts |
| Coriander | 📋 | | ⛔ | | 34451867 | Antileukemic Activity and Molecular Docking Study of a Polyphenolic Extract from Coriander Seeds |
| Creatine | 📋 | ✍ | ⛔ | | 18421708 | Creatine Monohydrate Attenuates Body Fat Accumulation in Children With Acute Lymphoblastic Leukemia During Maintenance Chemotherapy |
| Crocetin | 📋 | | | | 30203596 | Study of the mechanisms of crocetin-induced differentiation and apoptosis in human acute promyelocytic leukemia cells |
| Crocin | 📋 | ✍ | ⛔ | | 27398676 | The Effect and Mechanisms of Proliferative Inhibition of Crocin on Human Leukaemia Jurkat Cells |
| D-Mannose | 📋 | ✍ | ⛔ | | 35001876 | Effect of D-mannose on Philadelphia chromosome-positive leukemia cells |
| Daidzein | 📋 | ✍ | ⛔ | | 33603542 | Induction of cell death and modulation of Annexin A1 by phytoestrogens in human leukemic cell lines |
| Diallyl Trisulfide | 📋 | | | | 33109572 | Potentiation of Differentiation and Apoptosis in a Human Promyelocytic Leukemia Cell Line by Garlic Essential Oil and Its Organosulfur Compounds |
| Diosmin | 📋 | ✍ | ⛔ | | 33952791 | Anticancer and Anti-inflammatory Effect of Diosmin against Dalton Ascitic Lymphoma Induced Leukemia |
| Durian | 📋 | | ⛔ | | 37242300 | Elucidation of the Anticancer Mechanism of Durian Fruit ( Durio zibethinus) Pulp Extract in Human Leukemia (HL-60) Cancer Cells |
| Eclipta Alba | 📋 | ✍ | | | 34726823 | Environmental pollutant N-N'ethylnitrosourea-induced leukemic NLRP3 inflammasome activation and its amelioration by Eclipta prostrata and its active compound wedelolactone |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 26290393 | Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia |
| Eugenol | 📋 | | | | 31812013 | Could PCSK9 be a new therapeutic target of Eugenol? In vitro and in silico evaluation of hypothesis |
| Eurycomanone | 📋 | | | | 25230121 | Eurycomanone and eurycomanol from Eurycoma longifolia Jack as regulators of signaling pathways involved in proliferation, cell death and inflammation |
| Fenugreek | 📋 | ✍ | ⛔ | | 23110539 | Fenugreek Extract as an Inducer of Cellular Death via Autophagy in Human T Lymphoma Jurkat Cells |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 37846672 | [Inhibition of Ferulic Acid on U937 Cell Growth and Its Related Mechanism] |
| Feverfew | 📋 | ✍ | ⛔ | | 34060380 | Leukemia Chemoprevention and Therapeutic Potentials: Selected Medicinal Plants with Anti-Leukemic Activities |
| Fish Oil | 📋 | ✍ | ⛔ | | 32791015 | Effect of Fish Oil Supplementation on Hyperlipidemia during Childhood Acute Lymphoblastic Leukemia Treatment - A Pilot Study |
| Flavonoids | 📋 | | ⛔ | | 25588108 | Signaling Proteins and Pathways Affected by Flavonoids in Leukemia Cells |
| Folate | 📋 | ✍ | ⛔ | | 28588742 | Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature |
| Formononetin | 📋 | | | | 38459729 | Formononetin and Dihydroartemisinin Act Synergistically to Induce Apoptosis in Human Acute Myeloid Leukemia Cell Lines |
| Frankincense | 📋 | ✍ | ⛔ | | 38155908 | Boswellia carterii oleoresin extracts induce caspase-mediated apoptosis and G1 cell cycle arrest in human leukaemia subtypes |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 11426562 | Gamma-linolenic acid induces apoptosis in B-chronic lymphocytic leukaemia cells in vitro |
| Garlic | 📋 | ✍ | ⛔ | | 33109572 | Potentiation of Differentiation and Apoptosis in a Human Promyelocytic Leukemia Cell Line by Garlic Essential Oil and Its Organosulfur Compounds |
| Ginger | 📋 | ✍ | ⛔ | | 33757145 | A Novel Peptide Derived from Ginger Induces Apoptosis through the Modulation of p53, BAX, and BCL2 Expression in Leukemic Cell Lines |
| Ginger extract | 📋 | ✍ | ⛔ | | 31214760 | Ginger extract has anti-leukemia and anti-drug resistant effects on malignant cells |
| Ginkgetin | 📋 | | | | 28902633 | Ginkgetin inhibits proliferation of human leukemia cells via the TNF-α signaling pathway |
| Gotu Kola | 📋 | ✍ | ⛔ | | 35675643 | Centella asiatica Modulates Nrf-2 Antioxidant Mechanisms and Enhances Reactive Oxygen Species-Mediated Apoptotic Cell Death in Leukemic (THP-1) Cells |
| Grapefruit | 📋 | | ⛔ | | 36248996 | The successful combination of grapefruit juice and venetoclax in an unfit acute myeloid leukemia patient with adverse risk: A case report |
| Grapefruit Essential Oil | 📋 | ✍ | ⛔ | | 14758720 | Induction of apoptosis by Citrus paradisi essential oil in human leukemic (HL-60) cells |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 27465424 | Pure total flavonoids from Citrus paradisi Macfad induce leukemia cell apoptosis in vitro |
| Graviola | 📋 | ✍ | ⛔ | | 25539720 | Antiproliferative activity and induction of apoptosis by Annona muricata (Annonaceae) extract on human cancer cells |
| Green Tea | 📋 | ✍ | ⛔ | | 31452000 | Green Tea Consumption and Risk of Hematologic Neoplasms: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) |
| Hydroxytyrosol | 📋 | | | | 35806065 | Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity |
| Hypericin | 📋 | | | | 33723162 | Hypericin induces apoptosis in K562 cells via downregulation of Myc and Mdm2 |
| Icariin | 📋 | ✍ | | | 34540000 | Icaritin induces cellular senescence by accumulating the ROS production and regulation of the Jak2/Stat3/p21 pathway in imatinib-resistant, chronic myeloid leukemia cells |
| Icaritin | 📋 | | | | 38344310 | N-Ethyl-N-Nitrosourea Induced Leukaemia in a Mouse Model: Protective Effect of Icaritin via Inhibition of IL-6/JAK2/STAT3 Pathway Causes Apoptosis |
| Kale | 📋 | | | | 37048295 | Anti-Leukemic Effects on a U937 Cell Line of Fresh and Steamed Chinese Kale Juice and Their Pro-Apoptotic Effects via a Caspase-Dependent Pathway |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 31991893 | Apoptotic Effects on HL60 Human Leukaemia Cells Induced by Lavandin Essential Oil Treatment |
| Licochalcones | 📋 | | | | 38350590 | Licochalcone A induces mitochondria-dependent apoptosis and interacts with venetoclax in acute myeloid leukemia |
| Ligustilide | 📋 | | | | 38183698 | Dual role of Nrf2/HO-1 pathway in Z-ligustilide-induced ferroptosis against AML cells |
| Limonin | 📋 | | | | 33841805 | Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity |
| Linalool | 📋 | | ⛔ | | 32934748 | Linalool inhibits the growth of human T cell acute lymphoblastic leukemia cells with involvement of the MAPK signaling pathway |
| Malvidin | 📋 | | | | 12502387 | Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 21816083 | Activation of human T-helper/inducer cell, T-cytotoxic cell, B-cell, and natural killer (NK)-cells and induction of natural killer cell activity against K562 chronic myeloid leukemia cells with modified citrus pectin |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 25051949 | Chemopreventive and anti-leukemic effects of ethanol extracts of Moringa oleifera leaves on wistar rats bearing benzene induced leukemia |
| Mugwort | 📋 | | ⛔ | | 36382259 | Artemisia vulgaris inhibits BCR/ABL and promotes apoptosis in chronic myeloid leukemia cells |
| Mulberry | 📋 | | ⛔ | | 18350513 | In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells |
| Myrtle | 📋 | ✍ | ⛔ | | 36501085 | Antileukemic, Antioxidant, Anti-Inflammatory and Healing Activities Induced by a Polyphenol-Enriched Fraction Extracted from Leaves of Myrtus communis L |
| Nutmeg | 📋 | ✍ | ⛔ | | 24792648 | Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells |
| Oregano | 📋 | ✍ | ⛔ | | 27470342 | Cooperative antiproliferative and differentiation-enhancing activity of medicinal plant extracts in acute myeloid leukemia cells |
| Paeoniflorin | 📋 | | | | 35851125 | [Paeoniflorin induces apoptosis and cycle arrest in B-cell acute lymphoblastic leukemia cells by inhibiting SENP1/c-Myc signaling pathway] |
| Papaya | 📋 | ✍ | ⛔ | | 30662779 | The Use of Natural Health Products Especially Papaya Leaf Extract and Dandelion Root Extract in Previously Untreated Chronic Myelomonocytic Leukemia |
| Patchouli | 📋 | ✍ | ⛔ | | 34136185 | Pogostemon cablin extract as an anticancer agent on human acute myeloid leukemia |
| Peppermint | 📋 | ✍ | ⛔ | | 36923503 | Anti-leukemic effect of menthol, a peppermint compound, on induction of apoptosis and autophagy |
| Phytoestrogens | 📋 | | ⛔ | | 33603542 | Induction of cell death and modulation of Annexin A1 by phytoestrogens in human leukemic cell lines |
| Polyphenols | 📋 | | | | 33489451 | Therapy-related acute myeloid leukemia and its prevention |
| Procyanidins | 📋 | | ⛔ | | 37246327 | Mechanism of procyanidin b2 in the treatment of chronic myeloid leukemia based on integrating network pharmacology and molecular docking |
| Red Sage | 📋 | ✍ | ⛔ | | 29464799 | Antiproliferative activity and apoptosis induction by trijuganone C isolated from the root of Salvia miltiorrhiza Bunge (Danshen) |
| Rosehip | 📋 | ✍ | ⛔ | | 27470342 | Cooperative antiproliferative and differentiation-enhancing activity of medicinal plant extracts in acute myeloid leukemia cells |
| Saffron | 📋 | ✍ | ⛔ | | 30644127 | The Antileukemic Effects of Saffron (Crocus Sativus L.) and Its Related Molecular Targets: A Mini Review |
| Sage | 📋 | ✍ | ⛔ | | 27470342 | Cooperative antiproliferative and differentiation-enhancing activity of medicinal plant extracts in acute myeloid leukemia cells |
| Salvianolic Acid | 📋 | | | | 29164984 | Salvianolic acid A, a novel PI3K/Akt inhibitor, induces cell apoptosis and suppresses tumor growth in acute myeloid leukemia |
| Skullcap | 📋 | ✍ | ⛔ | | 34060380 | Leukemia Chemoprevention and Therapeutic Potentials: Selected Medicinal Plants with Anti-Leukemic Activities |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 16424868 | Pro-apoptotic Properties of Hyperforin in Leukemic Cells From Patients With B-cell Chronic Lymphocytic Leukemia |
| Star Anise | 📋 | ✍ | ⛔ | | 31915450 | Systemic Pharmacological Approach to Identification and Experimental Verification of the Effect of Anisi Stellati Fructus Extract on Chronic Myeloid Leukemia Cells |
| Sweet Potato | 📋 | | ⛔ | | 35924786 | Calcicoptosis induced by purple sweet potato anthocyanins through the nonosmotic regulation of the NFAT5/S100A4-S100A9 pathway in acute lymphoblastic leukemia |
| Tangeretin | 📋 | | | | 20077418 | The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562 |
| Tannic Acid | 📋 | ✍ | ⛔ | | 18790533 | Tannic acid-induced apoptosis and -enhanced sensitivity to arsenic trioxide in human leukemia HL-60 cells |
| Thyme | 📋 | ✍ | ⛔ | | 33138135 | Induction of Apoptosis, Autophagy and Ferroptosis by Thymus vulgaris and Arctium lappa Extract in Leukemia and Multiple Myeloma Cell Lines |
| Thymol | 📋 | ✍ | ⛔ | | 33466806 | New Anti-Leukemic Effect of Carvacrol and Thymol Combination through Synergistic Induction of Different Cell Death Pathways |
| Urolithins | 📋 | | | | 34067305 | Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 38144346 | Ursolic acid induces apoptosis and pyroptosis in Reh cells by upregulating of the JNK signalling pathway based on network pharmacology and experimental validation |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 32860849 | Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 26046133 | Vitamin K2 and Cotylenin A Synergistically Induce Monocytic Differentiation and Growth Arrest Along With the Suppression of c-MYC Expression and Induction of Cyclin G2 Expression in Human Leukemia HL-60 Cells |
| Walnut | 📋 | | ⛔ | | 28945497 | Antiproliferative Activity of Walnut (Juglans regia L.) Proteins and Walnut Protein Hydrolysates |
| Wasabi | 📋 | | ⛔ | | 37047794 | Anti-Cancer Effects of Oxygen-Atom-Modified Derivatives of Wasabi Components on Human Leukemia Cells |
| Whey Protein | 📋 | ✍ | ⛔ | | 37174290 | Utilization of Dairy By-Products as a Source of Functional and Health Compounds-The Role of Ovine Colostrum and Milk Whey on Chronic Myeloid Leukemia Cells |
